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• Circulating tumor DNA dynamics and clinical outcome in metastatic colorectal cancer patients undergoing front-line chemotherapy
• Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome
• Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm
• Genomic landscape of diffuse glioma revealed by whole genome sequencing
• Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer
• MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
• Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer
• Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
• Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
• The genomic landscape of 2,023 colorectal cancers
• Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
• Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
• Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
• Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping
• Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
• Phenotypic plasticity and genetic control in colorectal cancer evolution
• The co-evolution of the genome and epigenome in colorectal cancer
• Evolutionary dynamics of neoantigens in growing tumors
• Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
• Subclonal reconstruction of tumors by using machine learning and population genetics
• Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial
• Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
• A Big Bang model of human colorectal tumor growth