SOTTORIVALAB
SOTTORIVALAB
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Our research focus
Measure and predict cancer evolution
We use molecular information to quantify and predict tumour evolution in humans and patient-derived models.
Develop tools that combine AI with mechanistic modelling for oncology
We create Machine Learning methods integrated with mechanistic modelling based on statistical physics, spatial tissue simulations and stochastic branching processes.
Design evolutionary-informed treatments against cancer drug resistance
We develop model systems for experimental evolution to design novel treatment strategies that prevent and control the emergence of drug resistance.
As a result of our studies, we also made significant contributions to the debate on neutral evolution vs selection in cancer
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