Timon Heide

Latest

• Circulating tumor DNA dynamics and clinical outcome in metastatic colorectal cancer patients undergoing front-line chemotherapy
• Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
• Contribution of pks+ E. coli mutations to colorectal carcinogenesis
• Phenotypic plasticity and genetic control in colorectal cancer evolution
• The co-evolution of the genome and epigenome in colorectal cancer
• Subclonal reconstruction of tumors by using machine learning and population genetics
• Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial
• Quantification of subclonal selection in cancer from bulk sequencing data