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Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
Immune system control is a major hurdle that cancer evolution must circumvent. The relative timing and evolutionary dynamics of …
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Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
The genomic landscape of 2,023 colorectal cancers
Colorectal carcinoma (CRC) is a common cause of mortality1, but a comprehensive description of its genomic landscape is lacking2–9. …
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Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Reconstructing temporal cellular dynamics from static single-cell transcriptomics remains a major challenge. Methods based on RNA …
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Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measurements in …
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Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Stratified Medicine Paediatrics (SMPaeds) is the UK precision medicine programme offering rapid turnaround sequencing with clinical …
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Contribution of pks+ E. coli mutations to colorectal carcinogenesis
The dominant mutational signature in colorectal cancer genomes is C > T deamination (COSMIC Signature 1) and, in a small subgroup, …
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Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping
Cancer drug resistance is multi-factorial, driven by heritable (epi)genetic changes but also phenotypic plasticity. Here we dissect it …
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Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356 …
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Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
Phenotypic plasticity and genetic control in colorectal cancer evolution
Cancer evolution is driven by natural selection acting upon phenotypic trait variation. However, the extent to which phenotypic …
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Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma
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